Draft Genome Sequence of the Oxytetracycline-Producing Bacterium Streptomyces rimosus ATCC 10970
نویسندگان
چکیده
We report the draft genome of Streptomyces rimosus (ATCC 10970), a soil isolate that produces oxytetracycline, a commercially important and clinically useful antibiotic.
منابع مشابه
The temperate phages RP2 and RP3 of Streptomyces rimosus.
The oxytetracycline-producing Streptomyces rimosus strains R6-65 and R7 (ATCC 10970) are lysogenic for the two narrow-host-range phages RP2 and RP3. Both phages are released at low frequency from the lysogenic strains and form plaques on 'cured' S. rimosus strains. RP2 and RP3 are of similar shape with flexible tails and contain double-stranded DNA of about 70% G+C with cohesive ends (group B1 ...
متن کاملGenome Sequences of the Oxytetracycline Production Strain Streptomyces rimosus R6-500 and Two Mutants with Chromosomal Rearrangements
The genome sequence of Streptomyces rimosus R6-500, an industrially improved strain which produces high titers of the important antibiotic oxytetracycline, is reported, as well as the genome sequences of two derivatives arising due to the genetic instability of the strain.
متن کاملNitrosoguanidine Mutagenesis and Genome Shuffling Enhanced the Oxytetracycline Production of Streptomyces rimosus
This research is aimed to improve the oxytetracycline production from Streptomyces rimosus. Five relatively high oxytetracycline yielding strains were obtained by nitrosoguanidine mutation of the protoplast of initial oxytetracycline producing strain Streptomyces rimosus JH and then subjected to genome shuffling as parental strains. The protoplasts of the five parental strains were prepared and...
متن کاملGenetics of Streptomyces rimosus, the oxytetracycline producer.
From a genetic standpoint, Streptomyces rimosus is arguably the best-characterized industrial streptomycete as the producer of oxytetracycline and other tetracycline antibiotics. Although resistance to these antibiotics has reduced their clinical use in recent years, tetracyclines have an increasing role in the treatment of emerging infections and noninfective diseases. Procedures for in vivo a...
متن کاملDraft Genome Sequence of Thiostrepton-Producing Streptomyces azureus ATCC 14921
Streptomyces azureus ATCC 14921 belongs to the Streptomyces cyaneus cluster and is known to be a thiostrepton producer. Here, we report a draft genome sequence for this strain, consisting of 350 contigs containing a total of 8,790,525 bp, 8,164 predicted coding sequences, and a G+C content of 70.9%.
متن کامل